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pentobarbital will reduce the extent or result of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.pentobarbital will lower the extent or result of ixabepilone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Aged or debilitated sufferers might respond to bar